Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists

J Med Chem. 1982 Mar;25(3):207-10. doi: 10.1021/jm00345a002.
No abstract available

MeSH terms

  • Animals
  • Binding, Competitive / drug effects
  • Chemical Phenomena
  • Chemistry
  • Cimetidine / pharmacology
  • Dihydrotestosterone / metabolism
  • Dogs
  • Gastric Acid / metabolism*
  • Guinea Pigs
  • Histamine H2 Antagonists / chemical synthesis*
  • In Vitro Techniques
  • Mice
  • Muscle Contraction / drug effects
  • Rats
  • Stereoisomerism
  • Thiadiazoles / chemical synthesis*
  • Thiadiazoles / pharmacology
  • Urea / analogs & derivatives*
  • X-Ray Diffraction

Substances

  • Histamine H2 Antagonists
  • Thiadiazoles
  • Dihydrotestosterone
  • Cimetidine
  • Urea